J Psychopharmacol. 2008 Feb 28 [Epub ahead of print]

 

Involvement of sigma ({sigma}1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test.

 

Dhir A, Kulkarni SK. Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.

 

 

The present study investigated the effects of neurosteroids dehydroepiandrosterone sulfate (DHEAS) or pregnenolone sulfate (PS) on the tail-suspension test (TST) of depression in mice, and also the possible involvement of sigma (s) receptors. Immobility time in the TST was measured for a total period of 6 min. DHEAS (10 and 40mg/kg, s.c.) or PS (40mg/kg, s.c.) significantly reduced the immobility period without accompanying changes in the locomotor activity in mice. The effect on behavioural despair by DHEAS (10 and 40mg/kg, s.c.) and PS (40mg/kg, s.c.) was blocked by BD 1047 (1mg/kg, s.c.), a novel s1-receptor antagonist, progesterone (10mg/kg, s.c.), a s-receptor antagonistic neurosteroid or rimcazole (5mg/kg, s.c.), another s1-receptor antagonistic property, respectively. The treatments and their combination did not alter the motor activity in mice. These data suggested a role for the central s receptors particularly sigma-1 (s1) receptors in the anti-depressant-like effects of neurosteroids.

 

 

PMID: 18308813 [PubMed - as supplied by publisher]

 

 

 

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