Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

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Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

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Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity

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  Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289
  
  Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289
  
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Arch Environ Health. 2004 Jul;59(7):363-75.

 

The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity.

 

Pall ML, Anderson JH.

 

School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4234, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.

 

The vanilloid receptor (TRPV1 or VR1), widely distributed in the central and peripheral nervous system, is activated by a broad range of chemicals similar to those implicated in Multiple Chemical Sensitivity (MCS) Syndrome. The vanilloid receptor is reportedly hyperresponsive in MCS and can increase nitric oxide levels and stimulate N-methyl-D-aspartate (NMDA) receptor activity, both of which are important features in the previously proposed central role of nitric oxide and NMDA receptors in MCS. Vanilloid receptor activity is markedly altered by multiple mechanisms, possibly providing an explanation for the increased activity in MCS and symptom masking by previous chemical exposure. Activation of this receptor by certain mycotoxins may account for some cases of sick building syndrome, a frequent precursor of MCS. Twelve types of evidence implicate the vanilloid receptor as the major target of chemicals, including volatile organic solvents (but not pesticides) in MCS.

 

Publication Types:
Review

 

PMID: 16241041 [PubMed - indexed for MEDLINE]

 

 

 

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