SIBO and Candida/yeast overgrowth - a compounding factor in poor methylation?
As we all know, folate and vitamin B12 are critical to the methylation cycle. It follows that anything that reduces our supply of these nutrients will compromise our ability to methylate.
Most focus seems to be put on variations in the genes (single nucleotide polymorphisms - SNPs) that code for the enzymes involved in the methylation cycle when in the context of environmental illnesses and nutritional treatment regimes.
I'd suggest that anyone who appears to be a poor methylator and feels this is contributing to their illness (CFS, fibro, MCS, autism etc) consider their gut microflora. Small Intestinal Bacterial Overgrowth (SIBO) has been shown to be common in these conditions and has also been shown to reduce the availability of B12 - http://quintron-usa.com/images/pdfs/Support_Files/Certs_References/SIBO-Uninvited%20Guests.pdf
Overgrowth of Candida/yeast could be an even more detrimental factor since it also reduces availability of B12 and perhaps folate (need to dig up refs!) but additionally produces ethanol and acetaldehyde as products of fermentation and these substances deplete the body of B vitamins.
So I guess what I am saying is if you are not methylating efficiently and are chronically ill make sure to check for SNPS...and also gut dysbiosis!
Any thoughts or experiences anyone?
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