Home fecal transplant for ulcerative colitis / gut dysbiosis

Discussion started by MikeH 8 years ago

Thought i'd start a new discussion to chart my own progress. Unfortunately there isn't going to be much progress for the time being.

Had donor results back/interpreted yesterday. Mostly good except for signs of a possible pathogen Citrobacter braakii and also a general lack of good bacteria.

Worth doing to find out as even if the citrobacter didn't cause problems i wouldn't have been getting much of a dose of good bacteria anyway.

Donor is going on some anti-bacterials to get rid of citrobacter, then a period of flora restoration before we have to test again to check.

Looking like 2-3 months at least i'd say. Bit of a disappointment and frustration - i'd already started mapping out the next few months with my new healthy body!

Anyway not going to rest on my laurels. I'll carry on reintroducing greater variety of food into my diet and getting into lacto-fermentation, going to try and get off the prescription meds and see how I get on without them and also seriously thinking about trying vitamin E enemas. Not heard of anyone using it for anything except UC but i've got all the kit now and it might give me some temporary freedom!

Best of luck to everyone. I'll be keeping an eye on your progress.

 

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Bushi
Bushi
Hi guys, i've just posted this in the IBS section but thought i'd ask here to see if anyone knows anything Mesalazine.

I have recently been reading how it could help IBS-D symptoms. Mesalazine is supposed to be effective at reducing mast cell infiltration and I think it's usually used for colitis. Here's an extract from the below link:

"Mesalazine is known to have anti-inflammatory properties and is used in the treatment of inflammatory bowel diseases. Although its exact mechanism are still unknown(10, 20), several potential mechanisms have been suggested, including 5-aminosalicylate-induced inhibition of inflammation by interfering with the metabolism of arachidonic acid, prevention of mucosal generation of leukotrienes and PG(26) scavenging of free radicals(21, 26) and mechanisms only recently identified involving inhibition of nuclear factor-kappaB (NFκ and induction of apoptosis."

www.scielo.br/pdf/ag/v48n1/… anyone is interested, the University of Nottingham are currently running a trial with this drug and looking for volunteers.

Here'a another study and probably easier to read.
onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.04041.x/…]
8 years ago
Bushi
Bushi
Here's a new article on FTT. There's nothing new really here, but it's just good to see that it is hitting the press more and more!

But don't hold your breaths though for an 'Over the Counter Fecal Probiotic' any time soon by the sounds of it........

www.theaustralian.com.au/news/health-science/stool-solution-for-deadly-colitis/…
8 years ago
True
True
I too believe the donor banks are an awesome idea and probably not far off in the future..if big pharma doesnt get in the way.
8 years ago
Tracy Mac
Tracy Mac
Borody's Clinic in Sydney featured on an ABC Science show tonight here in Australia. You can see it here:

blogs.abc.net.au/catalyst/2011/07/…]
8 years ago
True
True
I am not sure this is the right spot for this question...
I am planning on doing the implant with my husband as the donor only I am now confused about the saline solution required. I assumed that contact lense solution would work, is this incorrect and if so where would I purchase it? I have read of success using water but then read that one doctor believed water would not work.

thanks
8 years ago
Maff
Maff
Tracy - Just read your latest blog posts and sorry to hear how things have gone backwards for you over the past 6 weeks. Still, your early response was definitely promising and shows you're on the right track. I think you have it spot on when you suggest you should probably have taken things more slowly regarding diet. You have been ill so long and there are numerous factors (e.g. gut permeability, food intolerences) that won't disappear over night. I think those of us with systemic, multi-system illnesses need to think of HPI is a jumpstart to a long-term strategy. Good luck with the next visit to CDD, I really hope it works out for you this time. Oh and I think you might be onto something with your online "donor bank" business idea...

Mike - Sorry for hijacking your discussion. You might need another one by the time you're ready to get going with your HPIs!
8 years ago
Tracy Mac
Tracy Mac
Yes I'm having difficult finding a donor too. I'm having a repeat session on Monday at the CDD in Sydney, but if I go backwards this time I cannot afford to go back there or take more time off work so will have to find a donor here in Melbourne. But having become so familiar with the range of ailments dysbiosis wreaks, I now see sick guts everywhere. The more I search the more I realise that most people I know have some kind of health problem that is, or could be gut related.

Then there is the requirement to find someone that is kind-hearted enough to help, isn't going to freak out at the request, will suffer the inconvenience of the tests and finally, be organised enough to remember to bring a take away food container to the loo - and call you to pick up the goods when they land!

I now understand why the CDD recommends their mix of three donors as they are 'proven'. I guess that's what you pay for.

Does anyone feel like they are living in a surreallist horror movie? One person's toxic waste could be my future life support. I can't believe that there are people all around me having a poo every day and flushing it down the loo while I am paying a fortune to fly to Sydney to buy 'quality poo with bonus anonymity"! Is this not an extremely modern existentialist conundrum?
8 years ago
Redozipous
Redozipous
I really wrote a some twenty line reply, but my cell stopped working just when I clicked post... I wrote mostly about how it's hard to find a totally "clean" donor. So, I agree with Maff. Good luck when you do go Mike.
8 years ago
Maff
Maff
Hi Mike,

Good to see you've started a new discussion to chart your progress...even if things have stalled a bit for the moment.

I recently read an article about faecal bacteriotherapy and a doctor said that it was a fantastic therapy with huge potential that would surely become more widely used but that it had one big drawback...almost nobody has what might be considered healthy gut flora thesedays. I think your donor's results probably highlight that. I assume they are "healthy" and were no doubt a bit shocked by the results? I am anxiously awaiting my own Metametrix GI Effects Profile results and those of my donor. I expect things won't be perfect there either...

Hope all goes well with the revised plan and the wait isn't too agonising. It sounds like you're making the right moves and putting your all into it!

Vitamin E enemas sound like they would be well worth a shot. I'd give them a go if I had UC. Hopefully it will reduce some inflammation and symptoms for you while you get the HPI situation more like it should be.

Keep us updated and all the best.
8 years ago

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