Methods for preparating / sterilisation of gut prior to HPI
This area is for discussing the pros and cons of different methods of sterilising the gut prior to HPI. This can include antibiotics, antifungals, biofilm breakers, etc.....
In my case I have been tested for gastric acid production and have no deficiency at all. In fact, using a Heidelberg pH probe I was found to be producing (around) 103% of "normal". So lack of gastric acid is not the problem, I suspect my problems are down to poor gut ecology from birth compounded by far too many courses of antibiotics through childhood. Dysfunctional GI immunity either as a result of this or independent of it would also be a likely factor.
In general if upper gut microbial overgrowth is the issue (as I believe you feel is the case for you Redo) perhaps top-down HPI is not advisable since it may simply undo the prep with antimicrobials and stimulate new overgrowth.
My feeling is that perhaps SCD/GAPS/PAleo type diets and long-term antimicrobial treatment is a better way to go. I know most of us have come to HPI because this approach has failed to bring significant benefit but in my experience at least it is itself not a "silver bullet".
Sorry to put a downer on things. It could of course be that my treatment methodology was inadequate e.g. capsule method of introducing donor faecal matter, amount of faecal matter, duration of treatment etc.
For colon-only issues I believe HPI has a much greater chance of success. The colon is supposed to be full of microbes...the small intestine is not.
The only good thing about my situation, which I have come to appreciate reading everyone else's stories, is that it is very clear to me that 100% of my problems come from my gut, particularly as it occurred as a result of anti-biotic over use in the first place. This is supported by the very encouraging results I had from my first two HPIs. Now all I have to do is get enough of it into me for long enough.
I am very concerned however that I have run out of options to 'prep' the gut pre HPI. That's why I was asking about Rife Machines. I have an appointment with an Ondamed Practiotioner next Thursday to try and kill off the strep that way. Just dreading telling my story to another practitioner though. If it works I think I will buy my own machine and use it in conjunction with the HPI. Any idea where I can get a reputable affordable Rike machine?
Thanks for the links Bushi, very interesting. Cedars Sinai are doing a lot of research in this area. I believe this is where Mark Pimentel does his work? Looks like combination antibiotic therapy is the way many researchers are now thinking for SIBO.
N.B. to view the first link posted by Bushi you'll need to copy and paste the link into your browser address bar and delete the "reduce" from the end so it finishes with .asp
I've tried erythromyacin (no effect) amoxicillin (limiting but not reducing effect) metronidazole (worked then became resistant) rifaximum (no effect) vancomyacin (couldn't tolerate) The only thing that worked was combination of metronidazole and erythromyacin but I can no longer tolerate the metrionadozole even if I wanted to.
Donor has now passed both poo tests (parasitology and ecology) with only blood tests to go. Donor has 90+% ecoli (unusual) and never gets travellers diareoh. Bioscreen lab were fascinated with his profile and thought we would be a good match!
www.wjgnet.com/1007-9327/13/… SIBO with IBS symptoms.
I also recently read somewhere recently that at Cedars Sinai Hospital in LA are currently testing with the following treatment for SIBO:
Rifaximin 1600 mg per day + Metronidazole (which i think is used to treat Helicobacter pylori) 750mg per day x 10 days . Supposedly the prelim results are quite promising.
The second link relates to enteric coated peppermint capsules and how they can help reducing SIBO. It also mentions CFS
Are your Bifidobacteria sp., Lactobaclli sp., and E.coli reported as non-existant or just low but within reference range on your faecal ecology test and was this Metametrix?
I hope your donor results come back soon so you can get moving with things!
This is the rationale of pulsed anti-bioitic therapy, 2 weeks on 2 weeks off. The two weeks off allows the bowel to recover from the anti-bioitics while you pump pro-bioitics, mutaflor etc into it - then you hit it again for two weeks to tackle the next reproductive cycle.
I am 'lucky' because my problem bugs are acid producing. This means that I can monitor objectively how well the anti-biotics are working by measuring my PH level. So I don't have to solely rely on 'do I feel better today' which can be influenced by so many things. (How many shades of 'bad' are there!)
I've tried a mind-boggling array of both pro-biotics (which I can no longer tolerate) and anti-biotics (which either no longer work or my liver can no longer tolerate). I've had two HPI treatments at the CDD in Australia which created a phenomenal turnaround but ultimately failed. So sustained HPI is my last option. I'm waiting for donor tests so that I can pursue this strategy for as long as it takes.
My fecal ecology tests show I have no ecoli, lactobacillus or bifido left in my gut and most of the 'bad' bugs are overgrown somewhat. However streptococcus is the stand-out culprit. Last test it was 80% of my aerobes (should be under 5%) and I am twice as bad since then so I reckon I've cracked the jackpot at 100% by now! Does anyone else have trouble with streptococcus overgrowth?
As for bowel prep prior to HPI I went with nystatin for Candida/yeast and rifaximin for bacteria. The sole reason for these choices was that both drugs are non-systemic i.e. not absorbed in an appreciable amount through the small intestinal wall. I have history of developing toxic hepatitis with systemic antimicrobials.
In a modest attempt to tackle biofilms I used a product called Interfase Plus by Klaire Labs which is primarily an enzyme formula (cellulase, hemicellulase etc) designed to digest the biofilm material. No way of telling whether this product was successful or not but it did not cause any adverse reactions despite also containing EDTA for metal chelation.
As I understand it, the breath tests are more reliable for the small/upper intestine bacterial overgrowth and the fecal tests for the large/lower intestine eg. my breath tests were clear as my problem is in the lower gut.
Which bacteria are methane producing?
Also would like opinions on whether or not a heavy metal cleanse would make any difference on the success of a transplant. Blood tests have shown very high levels of lead and semi high levels of mercury.
www.ncbi.nlm.nih.gov/pubmed/… seems to be the drug of choice for methane producing bacteria, although not as safe as rifaximin. The combination works wonders for constipation though!
Testing before and after fecal transplant
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