Low Dose Naltrexone (LDN) Support Low Dose Naltrexone (LDN) Support

Dr Jill Smith's Phase II trial results with Crohns and LDN

Discussion started by Viewpoint 11 years ago

I would like to share with the group the results (titled above) which I received from Dr Jill Smith - this is an excellent study/result to show how effective LDN is with Crohns:-

"Although the cause of Crohn's disease is unknown, research suggests it involves a complex interplay of environmental, genetic, microbial, immune and nonimmune factors," said Dr. Jill P. Smith, professor of medicine. "We hypothesize that the opioid system is involved in inflammatory bowel disease and that interfering with an opioid receptor will lead to the reversal of the inflammation."

Researchers studied 40 patients with active Crohn's disease. Patients received either naltrexone or a placebo for 12 weeks. All patients then continued on naltrexone for an additional 12 weeks. This was a double-blind study with neither the patient or healthcare provider knowing which treatment was being received.

Eighty-eight percent of those treated with naltrexone had at least a 70-point decline in Crohn's Disease Activity Index scores compared to 40 percent of placebo-treated patients. CDAI is a point system used to quantify symptoms in Crohn's patients. Researchers noted no statistical difference at four or eight weeks of treatment, suggesting a response requires at least 12 weeks of treatment. Results were published in the journal Digestive Diseases and Sciences.

Gastrointestinal inflammation was evaluated by appearance of the intestine on colonoscopy and scores from biopsy specimens. After 12 weeks, researchers noted no change in those taking a placebo. However, 78 percent of those on naltrexone experienced healing in the lining of the intestine.


I strongly encourage those who do live with this disease to look into LDN.  It can't do you any harm or have any nasty side effects like other meds being offered on the NHS. It is already available and in use in the UK.  This cost effective treatment only costs £17.50/month (private prescription). 



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