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TOPIC: Polyenylphosphatidylcholine for Oxidative Stress

Polyenylphosphatidylcholine for Oxidative Stress 12 years 5 months ago #1

  • bolam56
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After reading Dr. Martin Pall's writings on oxidative stress (NO/ONOO cycle), I started trying different antioxidants in an attempt to break the cycle. After having little results from the well known supplements, I started looking into some exotics.

I found \"Polyenylphosphatidylcholine\" (PPC) Trade names \"PPC\" (Source Naturals), \"PhosChol\" (from Nutrasal) and \"Hepatopro\" (LifeExtension/lef.org) really helped me. PPC promotes integrity of cell membranes and protects against glutathione loss. This was the first supplement I ever took that actually made me feel different (better!) in just a few days time. Brain fog lifted and tolerance to the daily onslaught of those nasty vapors improved quite a bit.

I don't want to raise false hopes; I just want to say this stuff has made me a lot better. Besides working on oxidative stress, It is also apparently very good for you! Helps regulate blood lipoproteins/peroxidation, cholesterol and many other lipid related functions.

This stuff ain't cheap, but I have found just one pill a day works ok for me. The best price I found was for PolyPC at iHerb.

I also take Trimethylglycine (TMG); to help maintain glutathione levels, which is a lot cheaper than SAM-e. Trimethylglycine donates a methyl group to convert homocysteine to methionine; methionine is then converted to SAMe by Methionine Adenosyl Transferase.

Next on my list was to be \"Fermented Papaya Extract\", trade name \"Immun'Age\" but wow is that stuff expensive! I may have to wait for a generic version.

I'm wondering if anyone else has tried these (or any others) and gotten results... I can't help but think, some antioxidant must be the key to treatment of NO/ONOO.<br /><br />Post edited by: bolam56, at: 2008/08/23 05:30
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Re:Polyenylphosphatidylcholine​ for Oxidative Stress 12 years 5 months ago #2

  • Maff
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Thanks for posting your experiences with these supplements. I have to say these are supplements that have a lot of research behind them, particularly PPC and SAMe.

Unfortunately my experience with them wasn't as positive as yours. I struggle with poor liver function so after reading all the positive research about PPC and SAMe in relation to liver disorders I gave them a try. Both caused irritation to my intestinal lining to the extent that I had to discontinue their use. I later tried TMG as an alternative and as a way to lower homocysteine levels but again had the same problem. I do have a very sensitive intestinal lining at the best of times for various reasons so perhaps others won't have so much trouble with them. Digestive upset is a known problem with SAMe however and it is recommended that it be taken with food to minimise problems. I presume the digestive upset is due to a mechanism related to it (and TMG) being a methyl doner.

Of course an alternative would be to get these nutrients intravenously. You may have heard of The Detoxx Book by John Foster MD, Patricia Kane PhD and Neal Speight MD? These doctors have developed a treatment protocol for what they call 'Chronic Neurotoxic Syndromes' (basically the illnesses this site covers) which is based on getting the balance of fats and phospholipids in the body right so cell membranes become healthy and the body is able to detoxify itself efficiently. Intravenous phosphatidylcholine is a major part of this protocol. As you might expect, this treatment protocol isn't cheap and I can't currently afford it to make any judgement on it! I'd love to hear from anybody who has experience with both the oral supplements bolam56 and I have tried as well as the Detoxx protocol.

Not sure if there will ever be a single antioxidant that will halt the NO/ONOO cycle, it's more likely that Martin Pall and other will come up with the best combination since antioxidants tend to work in synergy.

Having said that, let us know how you go with any other supplements you try ;)<br /><br />Post edited by: Maff, at: 2008/03/03 22:07
If you are going through hell, keep going - Winston Churchill
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Re:Polyenylphosphatidylcholine​ for Oxidative Stress 12 years 5 months ago #3

  • bolam56
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Hi Maff, Sorry you had tolerance problems with the PPC... Especially if you've got a sluggish liver. Were you able to give this a good run, or did you have an immediate adverse effect?

PPC is supposed to have a very protective effect on the GI tract... Found this on studies with PPC and NSAIDs:

\"Doses of aspirin as low as 30 mg suppress the production of protective prostaglandins in the gastric mucosa. In addition, aspirin's direct contact with the gastrointestinal tract interferes with the hydrophobic \"non-wettable\" properties that protect the underlying epithelium from gastric acid and other toxic substances. This characteristic seems to be attributable to an extracellular lining of phospholipids, which are synthesized in surface mucus cells of the stomach. Aspirin and other NSAIDs can rapidly transform the gastric mucosa from a non-wettable to a wettable state, thereby increasing the tissue's susceptibility to the corrosive actions of gastric acid.

A study on experimentally induced gastric ulcers in rats (Dunjic BS, et al., 1993) showed that mucosal lesions were significantly reduced by a single dose of PPC given before or after the injury factor, which in this study was ethanol or an NSAID.

A recent clinical trial compared the GI effects of aspirin to those of aspirin complexed with PPC (Anand BS et al., 1999). Sixteen healthy subjects were given either ten doses of aspirin or ten doses of the aspirin/PPC complex over a 72 hour period. After a \"washout\" period, subjects were switched over to the other medication for a 72 hour period.

Researchers counted the number of gastroduodenal erosions in each subject. Those taking aspirin had an average of 8.75 erosions, while those taking the aspirin/PPC complex averaged only 2.81 erosions. The protective effect of PPC was most apparent in those who were most susceptible to aspirin injury, and did not interfere with the therapeutic activity of the aspirin.\"

You might want to give this another try...
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Re:Polyenylphosphatidylcholine​ for Oxidative Stress 12 years 5 months ago #4

  • Maff
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Hi,

That's a really interesting study, thanks for posting. I did try the PPC (2 different brands I think) and had the negative reaction very quickly. I have a suspicion it may not actually be the PPC itself but the ethanol and other things it tends to come with in the capsules. I imagine the ethanol is used as a solvent for the PPC.

If you know of a PPC product that doesn't contain ethanol I'd be really grateful if you'd let me know and I'll give that a try.

Otherwise I'd have to try intravenous and I'd need to be making significantly more from this website than I do now to afford that ;)
If you are going through hell, keep going - Winston Churchill
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