Martin Pall, Ph.D., School of Molecular Biosciences, Washington State University, has identified the NO/ONOO- cycle - the stress-induced increase in the levels of nitric oxide and its oxidant product peroxynitrite, and the biochemical vicious cycle that keeps these levels chronically elevated - as a key mechanism underlying oxidative stress. Below are individual and full-spectrum antioxidant preparations that together may assist in down-regulating this NO/ONOO- cycle mechanism. These suggestions are intended as nutritional support, not as a replacement for medical treatment of any condition.
Professor Pall believes that the NO/ONOO- cycle is at the heart of many "unexplained illnesses" such as chronic fatigue syndrome (ME/CFS), fibromyalgia and multiple chemical sensitivity (MCS) as he discusses in his book 'Explaining Unexplained Illnesses: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome' and in the article The NO! OH NOO! Theory and Suggestions For Treatment.
The following are the individual nutritional supplements Professor Pall developed with Nutricology:
CoQ-Gamma E with Tocotrienols & Carotenoid
Take 1 softgel daily, in the morning. Some individuals may increase to 1 softgel two times daily, morning and mid-day.
Take 2 capsules, three times daily, with or following meals. Multivitamin/mineral with acetyl-L-carnitine and R-alpha-lipoic acid.
Take 1 capsule, three times daily, spread out over the day. Take one capsule in the middle of the night if one wakes up. Flavonoids are rapidly absorbed and excreted, substantially elevating blood levels for roughly four hours. Divided dosages can significantly support anti-oxidant levels in the body for longer periods.
NAC Enhanced Antioxidant Formula
Take 1 tablet, three times daily, following or with meals. At this dose, the modest amount of N-acetyl-L-cysteine will help avoid possible excitotoxicity.
Super EPA Fish Oil Concentrate
Take 1 softgel, one or two times daily. Take the first dose with the CoQ-Gamma E with Tocotrienols & Carotenoids. Lowers induction of inducible nitric oxide synthase, and has anti-inflammatory properties.
This polyphenol/phlorotannin supplement may be used in addition to the five above formulas, or in place of FlaviNOx. Take 1 capsule three times daily before meals.
Further information and instructions on how to take the supplements in the protocol can be found on the Nutricology website.
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